Flagyl Australia

Flagyl is an antibiotic from the chemical class of nitroimidazoles.flagyl
The main component in Flagyl is metronidazole.

It is an orally administered synthetically made antiprotozoal and antibacterial agent.

It is used to prevent and combat bacteria in the human body.

The medical purposes of the medication include the treatment of: bacterial infections of the vagina, stomach, skin, joints, and respiratory tract.

The extended-release tablets of Flagyl are indicated to treat vaginal infections caused by bacteria in women.
Metronidazole can be used for other medical purposes not included in the label of the medication. It effectively treats:
•    Clostridium difficile diarrhea or colitis (antibiotic-associated colitis).
•    Crohn’s disease.
•    Gastritis or stomach ulcers due to Helicobacter pylori.
•    Giardiasis (parasites).
Flagyl should be used only with a doctor’s prescription. The medication is produced in the form of extended release tablets, common tablet form, suspension and capsule form.

Metronidazole dosing

5Metronidazole administration depends on the individual conditions of a patient. In some patients the use of this medicine may demand use with food or milk to prevent stomach upset.

Generally Metronidazole can be used with food or without it. Tablets and capsules are taken orally in even intervals to make the medicine more effective.

Injections of this medicine are usually used for the treatment of serious infections when a person has to be in the hospital.

As the elimination of this medicine occurs in the liver mainly, the dosage of Metronidazole is determined by its function. In persons with liver damage or malfunction, the dosage of Metronidazole may be lower than in generally healthy patients. So liver disease and liver function are among the main things considered while prescribing the dosage of this medicine.

Other things which are kept in mind, include: general response of a person to the therapy, severity of the condition being treated, use of other medicines.

Different Metronidazole regimens are directed. For instance, amebic dysentery requires a patient using 750 mg of Metronidazole 3 times a day for a period of 5-10 days.

The following regimens are actually prescribed:

Amebic liver abscess 500-750 mg of Metronidazole orally 3times a day for a period of 5-10 days.doc

Bacterial vaginosis 750 mg of Metronidazole in the form of extended release tablets 1 time a day during 7 days /or 500 mg 2 times a day for 7 days.

PID (pelvic inflammatory disease) 500 mg 2 times a day during 2 weeks.

Trichomoniasis 2 g as a single dose.

Rosacea acne 1 g as a single dose and topical gel 0.75% once a day.

Giardia 250 mg of Metronidazole 3 times a day for 5 days.

helicHelicobacter pylori 800-1500 mg daily for several days in combination with other antibiotics.

Metronidazole must not be used in women patients who have the first trimester of pregnancy. The medicine can harm an unborn baby.

The same is applied to the nursing mothers.

The dosage of this medicine can be changed if necessary. All the dosage changes are regulated and made by a doctor. Do not change your dose of this medicine on your own.

If you want to get the fast and sure effect of this medicine, follow the advice and recommendations of your doctor. Do not take larger or smaller dosages of this medicine. Be attentive to your general health state.

3The medication is well absorbed in the stomach with max plasma concentrations within 1-2 hours post dose.

Plasma concentrations of Flagyl are dose-dependent. Higher doses of the medication produce higher peak plasma concentrations.

Metronidazole in unchanged form exists as the major component in the plasma, its metabolites also present. About 20% of the medication is bound to plasma proteins.

The medication in an unchanged form and its main metabolites possess bactericidal activity against most strains of anaerobic bacteria and trichomonacidal activity.

After administration the main component of the medication is found in cerebrospinal fluid, saliva, and human milk in concentrations similar to those found in plasma.4

The average elimination half-life in healthy patients is eight hours. The medication is eliminated mainly in the urine (up to 80%), about 6-15% in the feces.

Patients with impaired of reduced renal function do not have to take lower doses of the medication. Patients with liver impairment function have decreased clearance of  metronidazole. Thus the dose for such patients should be carefully considered.

Metronidazole information

Metronidazole medication is widely prescribed medicine for the treatment of different conditions related to bacteria-caused or protozoa-caused. This medicine is available under the brand name of Flagyl in local pharmacies as well as online.

Metronidazole is a prescription medicine meaning that your doctor should be in the know of your condition and suggest using this antibiotic.

Metronidazole is a generic name for the medicine which can be bought either under the brand or generic names.

The medicine is indicated for the treatment of different parasitic and bacterial infections of the body organs including amebic liver abscess, abdomen abscess, amebic dysentery, bacterial vaginosis, trichomonas vaginal infections, infections of the small intestine.2

This medicine can be used alone in a single therapy or in combination with other drugs (usually antibiotics) in treating the disorders produced by anaerobic bacteria such as pelvis or brain abscesses.

The high effectiveness of Metronidazole against a wide range of bacteria and protozoa makes it a drug of chose in the treatment of infections of the colon, pseudomembranous colitis, severe diarrhea conditions and other related conditions.

Metronidazole possesses high activity against a variety of anaerobic bacteria that is why it is applied in the form of creams and gels in patients with acne rosacea, bacterial vaginosis and other conditions.

It is often used in the treatment of stomach and intestinal ulcers related to Helicobacter pylori.hel

Broad spectrum of microbiological parameters of Metronidazole puts this medicine to the drugs of first-line therapy used in the treatment of severe or chronic disorders.

Being a potent antibiotic and anti-parasitic medicine, Metronidazole should be prescribed by the doctor under careful examination and lab tests. Self-treatment with this medicine is not recommended and can be dangerous if a person makes it improperly.

So, before using Metronidazole, visit your doctor for exact diagnosis and adjustment of the dosage. Do not change your dosage or skip doses during the treatment. Follow your doctor’s advice and learn about Metronidazole correct intake. The treatment with Metronidazole demands absolute avoidance of alcohol of any kind.

For more information ask your doctor.

Anaerobic bacteria:
bacteriaFlagyl is effective against most obligate anaerobes. Still the medication does not show any clinically significant effectiveness against facultative anaerobes or obligate aerobes.

The medication possesses bactericidal effects at therapeutic doses against the following organisms:
Anaerobic gram-negative:
Bacteroides species including the Bacteroides fragilis group (B. fragilis, B.
distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus)
Fusobacterium species
Anaerobic gram-positive:
Clostridium species and susceptible strains of Eubacterium
Anaerobic gram-positive cocci:
Peptococcus niger
Peptostreptococcus species

Trichomonas vaginalis and Entamoeba histolytica:
Flagyl has been detected to have constant trichomonacidal and amebacidal activity against T. vaginalis and E. histolytica.

Metronidazole is toxic to living cells of anaerobic bacteria, and such bacteria as Helicobacter pylori and Gardnerella vaginalis.

Its mechanism of action against susceptible bacteria takes place in a complex process having 4 different phases.11

First the medicine enters into the microorganism. Metronidazole possesses the low molecular weight helping it disperse and enter easily through the cell membranes of anaerobic and aerobic microorganisms.

Then the medicine toxicity against the microorganisms is activated by production of the free radicals, poisonous to the cells.

The medicine interacts with intracellular targets resulting in DNA breakage and ruining of the DNA spiral.

Finally the cell breaks down to the inert end substances.

12Metronidazole induces fast bactericidal effects against anaerobic bacteria. The medicine’s properties are increased with the dose increase.

For the treatment of certain conditions, the concentration-dependent ruining of the cells is very important. Such bacteria as Entamoeba histolytica and Trichomonas vaginalis, bacteroides fragilis and Clostridium perfringens are killed faster with the higher doses of Metronidazole.

Metronidazole is available under the brand name Flagyl and belongs to a group of medicines called antibiotics.

Flagyl can be used to treat:

• infections of the blood, brain, lung, bones, genital tract, pelvic area, stomach and intestines
• gum ulcers and other dental infections
• infected leg ulcers and pressure sores
• prevent infections after surgery

The medicine Flagyl should be used only when your doctor recommends you or prescribes you doing it.13

If you are taking other drugs, please tell your doctor about them before taking Flagyl.
Sometimes, there is a need for the combined treatment and your doctor may prescribe you using Flagyl with other antibiotics. Do not neglect your doctor’s advice. Follow all the prescriptions.

If you are not sure of safe using of Flagyl, please ask your doctor or pharmacist.
Driving and using machines is not affected by Flagyl. Still some patients may feel dizzy, sleepy or confused. They need to refrain from operating hazardous machinery or driving.

As the medicine is not recommended for chronic use, your doctor may ask your to undergo certain tests to evaluate your general health state. Please, follow all the directions of your caring doctor.

Flagyl may be used for the treatment of other infections and parasites. Your doctor may need to see your blood tests to adjust the proper dose of this medicine.